Age‐related decreases in basal limb blood flow in humans: time course, determinants and habitual exercise effects
Key result
Advancing age is associated with a progressive decline in basal whole-limb blood flow (r = -0.40, P<0.001) and vascular conductance, which is not modulated by habitual aerobic exercise.
Why the study?
Does habitual aerobic exercise modulate the age-related reduction in basal limb blood flow and vascular conductance in healthy men?
Population
Healthy men.
Comparison
Habitual physical activity and endurance… vs Sedentary lifestyle; younger age.
Design
Cross-sectional
Authors
Discussion
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Implication
Age-related decline in basal limb blood flow and conductance is unmodulated by exercise; leaves open mechanisms and intervention targets.
Study Design
Type
Cross-Sectional (n=231)
Structured PICO
Does habitual aerobic exercise modulate the age-related reduction in basal limb blood flow and vascular conductance in healthy men?
P
Population
231 healthy men aged 18 to 79 years, including sedentary, physically active, and endurance-trained individuals, assessed for basal limb blood flow.
E
Exposure
Habitual physical activity and endurance exercise training (Study 1); advancing age (Study 2).
C
Comparator
Sedentary lifestyle (Study 1); younger age (Study 2).
O
Outcome
Basal whole-leg (femoral artery) blood flow and vascular conductance.surrogate
Main Result
Effect estimate: r = -0.40
p-value: p=< 0.001
Basal whole-limb blood flow and vascular conductance decrease progressively with age in healthy men, are related to reductions in fat-free mass and oxygen consumption, and are not modulated by habitual aerobic exercise.
Cite This Study
Dinenno et al. (2001) conducted a cross-sectional in Healthy (n=231). Advancing age vs. Younger age was evaluated on Femoral blood flow (r = -0.40, p=< 0.001). Advancing age is associated with a progressive decline in basal whole-limb blood flow (r = -0.40, P<0.001) and vascular conductance, which is not modulated by habitual aerobic exercise.