Key result
Maternal age ≥30 years was significantly associated with an increased risk of anti-CMV IgG seropositivity among pregnant women (adjusted OR 2.08; 95% CI 1.10-3.94; p=0.025).
Why the study?
The study was conducted to investigate the seroprevalence of and risk factors for cytomegalovirus infection among pregnant women in southern Taiwan.
Cross-Sectional (n=456)
Yes
Odds Ratio: 2.08 (95% CI 1.1–3.94)
p-value: p=0.025
In southern Taiwan, CMV seroprevalence among pregnant women is high (87.28%), but primary infection is rare (0.65%), with maternal age ≥30 being a significant risk factor for seropositivity.
Maternal age ≥30 may inform targeted CMV counseling in prenatal care; leaves open whether this association predicts transmission or warrants screening changes.
OBJECTIVE: To investigate the seroprevalence of and risk factors for cytomegalovirus (CMV) infection among pregnant women in southern Taiwan. MATERIALS AND METHODS: From 2014 to 2015, pregnant women undergoing their first prenatal care visit participated in this study at Kaohsiung Chang Gung Memorial Hospital and Chiayi Chang Gung Memorial Hospital. A serologic test was performed for anti-CMV IgG/IgM. Transabdominal amniocentesis was scheduled for those with seropositive anti-CMV IgM. Extraction of CMV DNA was performed via real-time polymerase chain reaction (PCR). Maternal sociodemographic characteristics and risk factors for CMV seropositivity were analyzed. RESULTS: A total of 539 pregnant women undergoing their first prenatal visit were included. Eighty-three pregnant women were excluded for delivering at other hospitals. The overall seroprevalence rate of anti-CMV IgG in the remaining 456 cases was 87.28%. The seroprevalence rates of anti-CMV IgG(+)/IgM(+) and IgG(+)/IgM(-) were 1.32% and 85.96%, respectively. According to the anti-CMV IgG avidity test, only 3 pregnant women (0.65%) had primary CMV infection. Two of them underwent amniocentesis, and the results for both were negative for CMV DNA. According to the logistic regression analysis, the seropositivity of anti-CMV IgG was significantly associated with maternal age ≥30 (adjusted OR = 2.08, 95% CI: 1.10-3.94, p = 0.025) and the seropositivity of anti-CMV IgM was significantly associated with gestational weeks ≥37 when delivery (adjusted OR = 7.81, 95% CI: 1.23-49.58, p = 0.029). CONCLUSION: In southern Taiwan, among pregnant women, the CMV seroprevalence was high (87.28%), but the rate of primary CMV infection was very low (0.65%). Pregnant women aged more than 30 years had a significant risk of CMV seropositivity.
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Huang et al. (2022) conducted a cross-sectional in Cytomegalovirus (CMV) infection (n=456). Maternal age ≥30 years vs. Maternal age <30 years was evaluated on Seropositivity of anti-CMV IgG (adjusted OR 2.08, 95% CI 1.10-3.94, p=0.025). Maternal age ≥30 years was significantly associated with an increased risk of anti-CMV IgG seropositivity among pregnant women (adjusted OR 2.08; 95% CI 1.10-3.94; p=0.025).
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