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June 13, 2026Frontiers in ChemistryOpen Access

Semi-analytical Galerkin modeling of glucose transport and reaction in glucose oxidase-immobilized SBA-15 mesoporous silica

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Authors

JNJayalal J. NairTPT. Praveen

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Overview

Randomized trial examines glucose conversion in mesoporous silica, suggesting effective biosensor design principles.

Key Points

  • This work aims to develop a reaction-diffusion model to analyze glucose transport and enzymatic conversion in glucose oxidase-immobilized SBA-15 structures.
  • Developed a model incorporating diffusion, kinetics, and glucose exchange.
  • Utilized semi-analytical Galerkin method and Method of Lines for problem-solving.
  • Performed sensitivity analysis on competitive inhibition effects compared to diffusivity.
  • Achieved mean absolute percentage error below 1% against experimental data.
  • Validated model predictions demonstrate minimal errors in high enzyme loading and diffusion-limited conditions.
  • Identified competitive inhibition constant significantly influences glucose conversion compared to effective diffusivity.

Cite This Study

Nair et al. (2026) studied this question.

synapsesocial.com/papers/6a2cf2a9faef96ed7f055619https://doi.org/10.3389/fchem.2026.1848563
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