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June 13, 2026Asian Journal of Advanced Research and ReportsOpen Access

Clinical Outcomes in Donor-Specific Antibody–Negative Flow Cytometry Crossmatch–Positive Transplant Recipients: A Systematic Review

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Authors

MZMuhammed ZubairNLNaema LiaqatKKKulsoom Muhammad Ilyas Khan

Discussion

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Implication

Systematic review investigates outcomes in graft survival after donor-specific antibody-negative transplantation, suggesting careful recipient selection is vital.

Key Points

  • This review examines the outcomes of graft and patient survival in transplant recipients with donor-specific antibody-negative and flow cytometry crossmatch-positive results.
  • Conducted a literature search on PubMed, MEDLINE, Embase, and Cochrane Library.
  • Included studies were randomized controlled trials, cohort studies, and observational studies assessing outcomes.
  • Utilized qualitative narrative methods to synthesize data due to study heterogeneity.
  • Donor-specific antibody-negative flow cytometry crossmatch-positive transplantation showed positive correlations with graft and patient survival.
  • Increased early acute rejection episodes, including antibody-mediated rejection, were reported; however, these were often reversible.
  • Careful recipient selection and tailored immunosuppression improve long-term outcomes.

Cite This Study

Zubair et al. (2026) studied this question.

synapsesocial.com/papers/6a2cf2a9faef96ed7f05568chttps://doi.org/10.9734/ajarr/2026/v20i61388
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Risk Stratification Before Living Donor Kidney Transplantation in Patients With Preformed Donor-specific Antibodies by Different Crossmatch Methods2024 · 4 citations
  2. 2Crossing low/moderate‐level donor‐specific antibodies during heart transplantation2020 · 14 citations
  3. 3Correlation between virtual crossmatch, flow cytometric crossmatch and donor-specific alloantibodies in pretransplant evaluation for hematopoietic stem cell transplantation 2026
  4. 4Selective Elimination and Rationalization of Cell-based Assays in Deceased Donor Kidney Transplant Crossmatching2024
  5. 5Association of donor-specific antibodies with adverse outcomes in solid organ transplantation: A systematic review and meta-analysis of 69 studies2025 · 6 citations