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June 13, 2026Frontiers in Cell and Developmental BiologyOpen Access

Epigenetic regulation of cuproptosis in cancer: mechanisms, microenvironment, and therapeutic implications

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Authors

XZXin ZhangYYYixiao YuanLTLin Tang

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Overview

Randomized trial examines cuproptosis regulation in cancer, suggesting new therapeutic strategies with minimal toxicity.

Key Points

  • This research explores how epigenetic mechanisms and the tumor microenvironment influence cuproptosis in cancer cells.
  • Analysis of epigenetic mechanisms like DNA methylation and histone modifications in tumor cells.
  • Investigation of tumor microenvironment factors affecting copper availability and stress response.
  • Exploration of therapeutic strategies utilizing copper ionophores and nanomedicine.
  • Epigenetic mechanisms were found to significantly regulate copper homeostasis genes and lipoylation enzymes.
  • The tumor microenvironment shapes copper accumulation and influences immune response pathways.
  • Innovative treatments targeting these processes showed promise in selectively inducing cuproptosis in tumor cells.

Cite This Study

Zhang et al. (2026) studied this question.

synapsesocial.com/papers/6a2cf2a9faef96ed7f05575bhttps://doi.org/10.3389/fcell.2026.1814142
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