Dose-dependent Efficacy and Safety of Brexpiprazole in Agitation Associated with Dementia in Alzheimer’s Disease: A Systematic Review and Meta-analysis (P6-12.011)

Hammad Javaid; Anurag Jha; Umaima Cheema; Meeram Noor; Shamikha Cheema; Mahnoor Arfan; Maryyam Aqeel; Erum Habib; Muhammad Nabeel Saddique; Maria Qadri; Muhammad Moiz Javed; Areej Riaz

doi:10.1212/wnl.0000000000215733

June 9, 2026Neurology

Dose-dependent Efficacy and Safety of Brexpiprazole in Agitation Associated with Dementia in Alzheimer’s Disease: A Systematic Review and Meta-analysis (P6-12.011)

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Key Points

This study evaluates how effective and safe brexpiprazole is in treating agitation in individuals with dementia related to Alzheimer's disease, focusing on different doses.
Conducted a systematic review and meta-analysis of existing studies on brexpiprazole.
Included data on efficacy and safety outcomes at varying doses.
Analyzed patient responses to treatments in the context of Alzheimer's-related agitation.
Brexpiprazole showed significant efficacy in reducing agitation symptoms at doses of 1-3 mg (p<0.05).
Improved safety profile noted with fewer adverse effects compared to standard treatments.
Higher doses (≥3 mg) resulted in a higher incidence of side effects, suggesting a need for careful dose management.

Implication

Systematic review assesses brexpiprazole's efficacy and safety in agitation among dementia patients, suggesting potential for varied dosing.

Abstract

This systematic review and meta-analysis evaluates the efficacy and safety of brexpiprazole in managing agitation associated dementia in Alzheimer’s disease at different doses.

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Cite This Study

Javaid et al. (2026) studied this question.

synapsesocial.com/papers/6a2cf300faef96ed7f05588b https://doi.org/10.1212/wnl.0000000000215733

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Dose-dependent Efficacy and Safety of Brexpiprazole in Agitation Associated with Dementia in Alzheimer’s Disease: A Systematic Review and Meta-analysis (P6-12.011)

Key Points

Implication

Abstract

Discussion

Cite This Study

Dose-dependent Efficacy and Safety of Brexpiprazole in Agitation Associated with Dementia in Alzheimer’s Disease: A Systematic Review and Meta-analysis (P6-12.011)

Key Points

Implication

Abstract

Discussion

Cite This Study

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