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June 9, 2026Neurology

Antibody Negative West Nile Virus Encephalitis in a Patient on Anti-CD20 Therapy for Multiple Sclerosis (P11-3.005)

Thomas Draper Peter Mabie

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Key Points

To describe a case of antibody negative West Nile virus encephalitis in a patient receiving anti-CD20 therapy for multiple sclerosis.
Case report of a patient diagnosed with encephalitis
Patient was on anti-CD20 therapy for multiple sclerosis
The patient exhibited symptoms consistent with encephalitis, but tested negative for antibodies against West Nile virus.
Clinical implications suggest heightened awareness for infectious complications in patients on immunotherapy.

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Implication

Case report details encephalitis caused by West Nile virus in a patient undergoing anti-CD20 therapy, highlighting potential risks.

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Cite This Study

Draper et al. (2026) studied this question.

synapsesocial.com/papers/6a2cf300faef96ed7f0558b4 https://doi.org/10.1212/wnl.0000000000217394

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Bilateral Thalamic Involvement in West Nile Infection Linked to Anti-CD20 Therapy in a Patient with Multiple Sclerosis (P1-6.011)2024 · 2 citations
2Atypical Presentation of West Nile Encephalitis in an Immunosuppressed Patient: A Diagnostic Challenge (P11-3.009)Original Research · 2026
3Anti-CD20 Therapies Associated With Severe West Nile Neuroinvasive Disease (P11-3.012)Original Research · 2026
4Human antibodies against West Nile virus and related Orthoflaviviruses 91002025
5Case Report: First case of West Nile virus meningoencephalitis in Southwest Michigan in a patient on ixekizumab and prednisoneCase Report · 2026 · 1 citations

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Focal Limb Weakness Without Encephalopathy: An Atypical Presentation of West Nile Virus (P11-3.015)2026
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C50-32 West Nile Virus Presenting as Guillain-Barré Syndrome in an Immunocompromised Patient: A Diagnostic Challenge2026

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