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June 9, 2026Neurology

HSV Encephalitis: Non-classical PCR Results with a Classical Clinical Presentation in a 5-year Old Girl (P11-8.009)

Ruth Seleznick Victoria Mazo Alianis Tirado Elizabeth Fletcher Saba Ahmad

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Key Points

To highlight the diagnostic complexities of HSV encephalitis in a pediatric patient.
Case presentation of a 5-year-old girl with classical clinical symptoms of HSV encephalitis.
Assessment of PCR results that diverged from expected outcomes.
The clinical presentation was consistent with HSV encephalitis despite non-classical PCR results.
The case underscores the importance of clinical evaluation when interpreting PCR diagnostics.

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Implication

Case report shows unusual PCR results in a child with typical HSV encephalitis symptoms, suggesting diagnostic challenges.

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Cite This Study

Seleznick et al. (2026) studied this question.

synapsesocial.com/papers/6a2cf300faef96ed7f0558d3 https://doi.org/10.1212/wnl.0000000000216257

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Keep reading

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Challenges in the Diagnosis of Viral Encephalitis in Children: The Case of Two Siblingscase_report · 2022 · 2 citations
2A Clinical Diagnosis: False-negative CSF PCR in HSV-2-associated Elsberg Syndrome (P6-3.001)Original Research · 2026
3Anti-NMDAR Encephalitis in a 2-Year-Old Male Presenting with Acute Neuropsychiatric Changes (P10-1.010)Original Research · 2026
4Herpes Simplex Encephalitis with Two False-Negative Cerebrospinal Fluid PCR Tests and Review of Negative PCR Results in the Clinical SettingReview · 2011 · 47 citations
5Atypical Presentation of West Nile Encephalitis in an Immunosuppressed Patient: A Diagnostic Challenge (P11-3.009)Original Research · 2026

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