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June 9, 2026Neurology

A Clinical Diagnosis: False-negative CSF PCR in HSV-2-associated Elsberg Syndrome (P6-3.001)

Ameya Kale Melisha Budhathoki Alia Tewari Pooja Jethwani Priya Narwal

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Key Points

The aim is to highlight the diagnostic challenges posed by false-negative PCR results in HSV-2-associated Elsberg Syndrome.
Case report of a patient diagnosed with Elsberg Syndrome
Evaluation of cerebrospinal fluid (CSF) PCR for HSV-2
Analysis of clinical symptoms and diagnostic discrepancies
False-negative CSF PCR results were observed in the patient
Symptoms of Elsberg Syndrome were confirmed despite negative PCR
Diagnostic implications suggest careful evaluation of PCR results in suspect cases

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Implication

Case report uncovers false-negative PCR results in HSV-2-related Elsberg Syndrome, suggesting diagnostic challenges.

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Cite This Study

Kale et al. (2026) studied this question.

synapsesocial.com/papers/6a2cf403faef96ed7f056673 https://doi.org/10.1212/wnl.0000000000216491

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Keep reading

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Herpes Simplex Encephalitis with Two False-Negative Cerebrospinal Fluid PCR Tests and Review of Negative PCR Results in the Clinical SettingReview · 2011 · 47 citations
2Elsberg Syndrome Associated With HSV-2: Case Report of a Rare Neuroinfectious Disease (P7-3.006)Case Report · 2026
3Elsberg Syndrome With Albuminocytologic Dissociation - A Guillain-Barré Syndrome Mimic or Guillain-Barré Syndrome Variant?2024 · 1 citations
4Concurrent Detection of Streptococcus pneumoniae and Herpes Simplex Virus Type 1 (HSV-1) in Cerebrospinal Fluid: Clinical Interpretation Beyond Molecular PositivityOriginal Research · 2026
5HSV Encephalitis: Non-classical PCR Results with a Classical Clinical Presentation in a 5-year Old Girl (P11-8.009)Original Research · 2026

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