What does this research mean for the field?

October 1, 1990Journal of Medical Virology

Establishment of PCR for the early diagnosis of herpes simplex encephalitis

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Why the study?

Does PCR-based amplification of HSV-DNA in CSF accurately diagnose early herpes simplex encephalitis?

Population

CSF samples from 6 patients with confirmed herpes simplex encephalitis, 1 HSV 2-infected child, and 42…

Design

Other

Authors

EPElisabeth Puchhammer‐StöcklMedical University of Vienna TPTherese Popow‐KrauppMedical University of Vienna FHFranz X. HeinzMedical University of Vienna

Discussion

Member takes

Implication

Supports CSF PCR for suspected early HSE; leaves open larger prospective validation.

Structured PICO

Does PCR-based amplification of HSV-DNA in CSF accurately diagnose early herpes simplex encephalitis?

Population

CSF samples from 6 patients with confirmed herpes simplex encephalitis (HSE), 1 HSV 2-infected child, and 42 patients suffering from other diseases of the CNS

Intervention

PCR for specific amplification of HSV-DNA in cerebrospinal fluid (CSF) followed by oligonucleotide hybridization

Outcome

Detection of HSV DNA (diagnostic sensitivity and specificity)surrogate

PCR-based detection of HSV DNA in cerebrospinal fluid is a highly sensitive and specific tool for the early diagnosis of herpes simplex encephalitis.

Cite This Study

Puchhammer‐Stöckl et al. (1990) studied this question.

synapsesocial.com/papers/6a19e01b3f3ec013f0df3016 https://doi.org/10.1002/jmv.1890320202

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Establishment of PCR for the early diagnosis of herpes simplex encephalitis

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Establishment of PCR for the early diagnosis of herpes simplex encephalitis

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

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