Key result
Real-time PCR detected the HSV genome in 9.3% (22/236) of suspected herpes simplex encephalitis patients, with viral loads ranging from 2.5 × 10² to 1.7 × 10⁶ copies/mL of CSF.
Why the study?
Does quantitative Real-Time PCR of HSV DNA in CSF help evaluate the efficacy of antiviral therapy in patients with suspected herpes simplex encephalitis?
Population
236 consecutive patients with suspected herpes simplex encephalitis, 137 males and 99 females
Design
Cohort
Authors
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May support qPCR monitoring of antiviral response in suspected HSE; hypothesis-generating and needs prospective validation.
Observational (n=236)
Does quantitative Real-Time PCR of HSV DNA in CSF help evaluate the efficacy of antiviral therapy in patients with suspected herpes simplex encephalitis?
Quantitative PCR detection of HSV DNA in CSF can be helpful in evaluating the efficacy of antiviral therapy in patients with suspected herpes simplex encephalitis.
Ziyaeyan et al. (2011) conducted an observational in Suspected herpes simplex encephalitis (n=236). Real-time PCR for HSV DNA quantitation was evaluated on Detection of HSV genome and viral load quantitation. Real-time PCR detected the HSV genome in 9.3% (22/236) of suspected herpes simplex encephalitis patients, with viral loads ranging from 2.5 × 10² to 1.7 × 10⁶ copies/mL of CSF.
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