Why the study?
Do PCR and IEF accurately diagnose herpes simplex virus encephalitis in neurological patients?
Population
55 neurological patients, including 14 with clinically diagnosed herpes simplex virus encephalitis, 17 with…
Comparison
Herpes simplex virus-specific polymerase chain… vs Clinical diagnosis and other serological methods
Design
Cross-sectional
Authors
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Supports PCR/IEF diagnostic utility for HSVE; hypothesis-generating and requires prospective validation before routine use.
Do PCR and IEF accurately diagnose herpes simplex virus encephalitis in neurological patients?
PCR and IEF are effective methods for the unequivocal demonstration of HSV-specific CNS involvement and should be introduced in routine diagnosis of viral encephalitis.
Pohl‐Koppe et al. (1992) studied this question.
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