Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
June 13, 2026ACS Applied Materials & Interfaces

Potentiating Paclitaxel with its Homologous Nanovesicles: A Synergistic Strategy for Triple-Negative Breast Cancer Therapy

View Full Paper
Ask AI
Bookmark
Share

Authors

LLLi LiuYYYajuan YanJZJiao Zhang

Discussion

Loading...

Member takes

Overview

Randomized trial shows enhanced anti-TNBC effects with TLENs and paclitaxel, indicating a novel therapy strategy.

Key Points

  • The aim is to evaluate the effectiveness of Taxus leaf-derived nanovesicles in enhancing paclitaxel therapy for TNBC.
  • Developed natural extracellular nanovesicles from Taxus leaves for therapy delivery.
  • Assessed drug sensitivity and cellular mechanisms via metabolomics and LC-MS/MS analysis.
  • Evaluated effects on tumor microenvironment and immune response in TNBC models.
  • TLENs demonstrated significant anti-TNBC effects and improved paclitaxel sensitivity (p<0.05).
  • Oral coadministration of TLENs and PTX enhanced cytotoxic CD8+ T cell infiltration and reduced Tregs and myeloid-derived suppressor cells.
  • The treatment effectively restructured the tumor microenvironment, promoting immune activity against TNBC.

Cite This Study

Liu et al. (2026) studied this question.

synapsesocial.com/papers/6a2cf300faef96ed7f0558fbhttps://doi.org/10.1021/acsami.6c05220
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Plant-derived extracellular nanovesicles: a promising biomedical approach for effective targeting of triple negative breast cancer cells2024 · 9 citations
  2. 2Intelligent Biomimetic Nanoplatform for Systemic Treatment of Metastatic Triple-Negative Breast Cancer <i>via</i> Enhanced EGFR-Targeted Therapy and Immunotherapy2022 · 28 citations
  3. 3Recent Advances in Plant-Derived Extracellular Vesicles as Nanoparticles for Cancer Drug Delivery2025 · 24 citations
  4. 4Modular Design of Mesoporous Silica Nanoparticles Enables Bioimaging, Dual Chemotherapy, and Combinatorial Gene Silencing in Triple-Negative Breast Cancer2025 · 3 citations
  5. 5All-Small-Molecule Supramolecular Hydrogel Combining Self-Delivery and ROS-Responsive Release for Inhibiting Tumor Growth and Postoperative Recurrence2025 · 12 citations