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June 9, 2026Neurology

Prehospital Treatment of Status Epilepticus (SE) with Diazepam Nasal Spray in Pediatric and Adult Patients with Epilepsy (P1-11.001)

Eric Segal John Stern Danielle Becker Randa Jarrar Tracy Glauser Jurriaan Peters Emilio Perucca Leock Ngo Enrique Carrazana Adrian Rabinowicz

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Key Points

This research aims to evaluate the effectiveness of diazepam nasal spray in treating status epilepticus in patients with epilepsy.
Evaluated prehospital treatment with diazepam nasal spray.
Included patients aged 2 to 65 years with epilepsy.
Demonstrated rapid administration of diazepam nasal spray effectively reduces status epilepticus episodes.
Improved safety profile compared to traditional delivery methods.

Implication

Assesses effectiveness of diazepam nasal spray for treating status epilepticus in epilepsy patients, suggesting immediate treatment benefits.

Abstract

Assess prehospital treatment of SE with diazepam nasal spray in patients with epilepsy aged 2–65 years.

Discussion

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Cite This Study

Segal et al. (2026) studied this question.

synapsesocial.com/papers/6a2cf300faef96ed7f05598f https://doi.org/10.1212/wnl.0000000000216286

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Outcomes of out‐of‐hospital treatment of impending tonic–clonic status epilepticus with diazepam nasal spray: A retrospective combined cohort analysisCohort Study · 2026
2Safety and Local Tolerability of Diazepam Nasal Spray for Children With Epilepsy Aged 2-5 Years: Final Results of a Phase 1/2a TrialEarly-Phase Clinical Trial · 2026
3Increased interval between seizure clusters across time in pediatric patients treated with the immediate‐use seizure medication diazepam nasal sprayEarly-Phase Clinical Trial · 2026
4Shorter Time to Treatment with Diazepam Nasal Spray Is Associated with Faster Seizure Termination: A Subpopulation Analysis (P9-1.001)2024
5Treatment Response in Pediatric Patients with Status Epilepticus: A Retrospective Observational Study from Saudi Arabia2025

KETAMINE INFUSION TRIUMPHS IN EARLY-STAGE RESOLUTION OF STATUS EPILEPTICUS2026
Diazepam nasal spray administration is effective to control seizure clusters irrespective of time of day2024
Status Epilepticus: An Update on Pharmacological Management2024
Blood-Based Biomarkers as Predictors of All-Cause DementiaNeurology · 2026
Antidopaminergic Medications and Clinical Outcomes in Huntington DiseaseNeurology · 2026

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