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June 9, 2026Neurology

Fixed Dilated Pupils in Severe Traumatic Brain Injury: Revisiting Prognostic Certainty Through Cases of Functional Recovery (P1-18.003)

Diana Marzouk Jayant Totlani William Mualem Ehsaun Heydari Andrew Caras Kelsey Atkinson Zachary Rollins Kathleen Nealon Joseph Bell Brian Cameron John Greer Fazila Aseem

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Key Points

This research aims to evaluate whether fixed dilated pupils accurately predict mortality and outcomes in traumatic brain injury cases.
Analysis of cases with fixed dilated pupils in the context of traumatic brain injury.
Assessment of patient outcomes and recovery status post-injury.
Fixed dilated pupils were found to overestimate mortality risk in some cases.
Patients with fixed dilated pupils exhibited instances of functional recovery, challenging previous assumptions.

Implication

Case analysis reveals that fixed dilated pupils may inaccurately predict mortality in traumatic brain injury, indicating potential for recovery.

Abstract

To demonstrate that fixed dilated pupils (FDP) may overestimate mortality and unfavorable outcomes in acute phases of traumatic brain injury (TBI).

Discussion

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Cite This Study

Marzouk et al. (2026) studied this question.

synapsesocial.com/papers/6a2cf32afaef96ed7f055a32 https://doi.org/10.1212/wnl.0000000000216929

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Keep reading

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Saved by the Pupillometer! – A role for pupillometry in the acute assessment of patients with traumatic brain injuries?Original Research · 2018 · 27 citations
2Hope When it Appears Hopeless: A Review of Need for Surgical Decompression in Severe TBI Patients with Fixed Dilated Pupils2025
3Quantitative Pupillometry Predicts Return to Play and Tracks the Clinical Evolution of Mild Traumatic Brain Injury in US Military Academy Cadets: A Military Traumatic Brain Injury Initiative Study2024 · 5 citations
4Quantitative pupillometry as a sensitive biomarker for detecting subtle neurological impairment in mild traumatic brain injury – a pilot study2025
5Replication and Expansion of Pupillary Light Reflex as Diagnostic Mild Traumatic Brain Injury Tool in Military CadetsOriginal Research · 2026