Calcitonin Gene-related Peptide Induces Headache Attacks in People with Idiopathic Intracranial Hypertension (S23.004)

Andreas Yiangou; Thien Phu; Susan Mollan; Mark Thaller; James Mitchell; Georgios Tsermoulas; Lisa Hill; Samuel J.E. Lucas; Messoud Ashina; Alexandra Sinclair

doi:10.1212/wnl.0000000000216208

June 9, 2026Neurology

Calcitonin Gene-related Peptide Induces Headache Attacks in People with Idiopathic Intracranial Hypertension (S23.004)

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Key Points

The study aims to determine if calcitonin gene-related peptide triggers headache attacks in individuals with idiopathic intracranial hypertension compared to placebo.
Participants received either calcitonin gene-related peptide or placebo.
Headache attack frequency and intensity were measured and compared.
CGRP significantly provoked headache attacks compared to placebo in individuals with idiopathic intracranial hypertension.

Implication

Randomized trial investigates CGRP's role in provoking headache attacks in idiopathic intracranial hypertension, suggesting a novel treatment target.

Abstract

To determine whether calcitonin gene-related peptide (CGRP) provokes typical idiopathic intracranial hypertension (IIH) headache attacks compared with placebo.

Discussion

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Cite This Study

Yiangou et al. (2026) studied this question.

synapsesocial.com/papers/6a2cf32afaef96ed7f055a44 https://doi.org/10.1212/wnl.0000000000216208

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Calcitonin Gene-related Peptide Induces Headache Attacks in People with Idiopathic Intracranial Hypertension (S23.004)

Key Points

Implication

Abstract

Discussion

Cite This Study

Calcitonin Gene-related Peptide Induces Headache Attacks in People with Idiopathic Intracranial Hypertension (S23.004)

Key Points

Implication

Abstract

Discussion

Cite This Study

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