Tumor Inflammation Associated Neurotoxicity (TIAN) is Associated With Improved Outcomes in CNS Lymphoma Treated With CD19-CAR T-cell Therapy (S28.005)

Jorg Dietrich; Philipp Karschnia; Maria Martinez-Lage; Jeremy Abramson; Sofia Doubrovinskaia; Ganesh Shankar; Bryan Choi; Felix Ehret; Jeffrey Barnes; Areej El-Jawahri; Ephraim Hochberg; Patrick C. Johnson; Jacob Soumerai; Scott Plotkin; Tracy Batchelor; Wolfgang Wick; Yi-Bin Chen; Marcela Maus; Matthew Frigault; Leon Kaulen

doi:10.1212/wnl.0000000000217118

Key Points

This research aims to characterize the effects of Tumor Inflammation Associated Neurotoxicity (TIAN) in patients with CNS lymphoma undergoing CD19-CAR T-cell therapy.
Characterization of clinical presentation of TIAN in CNS lymphoma patients
Analysis of patterns and outcomes related to CD19-CAR T-cell therapy
Patients exhibiting TIAN showed improved treatment outcomes with CD19-CAR T-cell therapy
Specific patterns of neurotoxicity were identified that correlate with positive treatment effects

Implication

Identifies tumor inflammation associated neurotoxicity as beneficial in CNS lymphoma, suggesting positive treatment outcomes.

Abstract

To comprehensively characterize the clinical presentation and pattern of Tumor Inflammation Associated Neurotoxicity (TIAN) in CNS lymphoma (CNSL) patients treated with CD19-CAR-T cells.

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Cite This Study

Dietrich et al. (2026) studied this question.

synapsesocial.com/papers/6a2cf32afaef96ed7f055a59 https://doi.org/10.1212/wnl.0000000000217118

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Tumor Inflammation Associated Neurotoxicity (TIAN) is Associated With Improved Outcomes in CNS Lymphoma Treated With CD19-CAR T-cell Therapy (S28.005)

Key Points

Implication

Abstract

Discussion

Cite This Study

Tumor Inflammation Associated Neurotoxicity (TIAN) is Associated With Improved Outcomes in CNS Lymphoma Treated With CD19-CAR T-cell Therapy (S28.005)

Key Points

Implication

Abstract

Discussion

Cite This Study

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