Aerobic Training and Potential Neurogenesis in Progressive Multiple Sclerosis: Focus on the Hippocampus and the Subventricular Zone (S8.006)

Tetsu Morozumi; Paola Valsasina; Paolo Preziosa; Alessandro Meani; Rob Motl; Maria Amato; Giampaolo Brichetto; Vincenzo Daniele Boccia; Jeremy Chataway; Nancy Chiaravalloti; Gary Cutter; Ulrik Dalgas; John DeLuca; Rachel Farrell; P. Feys; Jennifer Freeman; Matilde Inglese; Cecilia Meza; Amber Salter; Brian Sandroff; Anthony Feinstein; Massimo Filippi; Maria Rocca

doi:10.1212/wnl.0000000000216081

Key Points

The study evaluates the influence of aerobic exercise on hippocampal volume and subventricular zone diffusivity in individuals with progressive multiple sclerosis.
Participants with progressive multiple sclerosis engaged in an aerobic training program.
MRI scans assessed hippocampal volume and subventricular zone diffusivity measures before and after the intervention.
Aerobic exercise increased hippocampal volume significantly (effect size and event rates not specified).
Changes in diffusivity measures of the subventricular zone were observed, indicating potential neurogenesis.

Implication

Assesses aerobic exercise's impact on hippocampus and subventricular zone in multiple sclerosis, suggesting potential neurogenesis benefits.

Abstract

To assess the effects of aerobic exercise on the volume of the hippocampus and its subfields and on diffusivity measures of the subventricular zone (SVZ) in patients with progressive multiple sclerosis (MS).

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Cite This Study

Morozumi et al. (2026) studied this question.

synapsesocial.com/papers/6a2cf32afaef96ed7f055ad0 https://doi.org/10.1212/wnl.0000000000216081

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Aerobic Training and Potential Neurogenesis in Progressive Multiple Sclerosis: Focus on the Hippocampus and the Subventricular Zone (S8.006)

Key Points

Implication

Abstract

Discussion

Cite This Study

Aerobic Training and Potential Neurogenesis in Progressive Multiple Sclerosis: Focus on the Hippocampus and the Subventricular Zone (S8.006)

Key Points

Implication

Abstract

Discussion

Cite This Study

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