A CSF Disease-associated Macrophage Signature Defines Progressive Multiple Sclerosis (S8.008)

Q: What does this research mean for the field?

A specific disease-associated macrophage signature in the cerebrospinal fluid characterizes and distinguishes progressive multiple sclerosis from relapsing disease stages. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

Raphaël Bernard‐Valnet; Anna‐Lena Börsch; Frederike Straeten; Andreas Schulte‐Mecklenbeck; Michael Heming; Louisa Müller-Miny; Xuesong Wang; Catharina C. Gross; Gerd Meyer zu Hörste

doi:10.1212/wnl.0000000000216337

June 9, 2026Neurology

A CSF Disease-associated Macrophage Signature Defines Progressive Multiple Sclerosis (S8.008)

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Key Points

This research aims to understand immune changes in cerebrospinal fluid related to progressive multiple sclerosis, distinguishing it from relapsing stages.
Characterized cerebrospinal fluid immune alterations in multiple sclerosis patients.
Identified cellular signatures unique to progressive and relapsing disease stages.
Identified a distinct macrophage signature in cerebrospinal fluid of patients with progressive multiple sclerosis.
The specific immune alterations correlate with disease progression and differ significantly from relapsing stages.

Implication

Characterizes immune alterations in progressive multiple sclerosis, indicating distinct cellular signatures.

Abstract

To characterize cerebrospinal fluid (CSF) immune alterations associated with progressive multiple sclerosis (PMS) and identify cellular signatures distinguishing progressive from relapsing disease stages.

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Cite This Study

Bernard‐Valnet et al. (2026) studied this question.

synapsesocial.com/papers/6a2cf32afaef96ed7f055add https://doi.org/10.1212/wnl.0000000000216337

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A CSF Disease-associated Macrophage Signature Defines Progressive Multiple Sclerosis (S8.008)

Key Points

Implication

Abstract

Discussion

Cite This Study

A CSF Disease-associated Macrophage Signature Defines Progressive Multiple Sclerosis (S8.008)

Key Points

Implication

Abstract

Discussion

Cite This Study

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