Subacute-onset Progressive Supranuclear Palsy-like Syndrome with Positive Anti-glycine Antibodies (P7-17.012)

Q: What does this research mean for the field?

Anti-glycine antibodies can cause a subacute-onset syndrome that mimics progressive supranuclear palsy (PSP), indicating a potential autoimmune etiology for certain movement disorders. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

Mattia Rosso; Danielle Reynolds; Lindsay McAlpine; Carolyn Fredericks; Veronica Santini

doi:10.1212/wnl.0000000000216529

June 9, 2026Neurology

Subacute-onset Progressive Supranuclear Palsy-like Syndrome with Positive Anti-glycine Antibodies (P7-17.012)

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Key Points

This report aims to describe cases of syndromes that resemble progressive supranuclear palsy (PSP) and to discuss the significance of autoimmune antibodies in these disorders.
Described two cases of movement disorders positive for anti-glycine antibodies
Focused on clinical symptoms that mimic progressive supranuclear palsy
Demonstrated distinctive features of anti-glycine antibody-related syndromes
Emphasized the potential misdiagnosis of degenerative diseases in the presence of autoimmune antibodies

Implication

Case report highlights anti-glycine antibody-positive movement disorders mimicking PSP, suggesting autoimmune implications.

Abstract

To report two cases of anti-glycine antibody-positive syndromes mimicking progressive supranuclear palsy (PSP) and to emphasize the role of autoimmune antibodies in movement disorders.

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Cite This Study

Rosso et al. (2026) studied this question.

synapsesocial.com/papers/6a2cf32afaef96ed7f055ade https://doi.org/10.1212/wnl.0000000000216529

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Subacute-onset Progressive Supranuclear Palsy-like Syndrome with Positive Anti-glycine Antibodies (P7-17.012)

Key Points

Implication

Abstract

Discussion

Cite This Study

Subacute-onset Progressive Supranuclear Palsy-like Syndrome with Positive Anti-glycine Antibodies (P7-17.012)

Key Points

Implication

Abstract

Discussion

Cite This Study

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