Effects of Vitamin D Supplementation on Disease Activity after a Clinically Isolated Syndrome According to Plasma Vitamin D Levels: Ancillary Analysis of the D-lay MS Randomized Controlled Trial (P7-19.005)

Manon Rival; Christophe Dematteï; Lysiane Boulet; Thibault Mura; Hanane Agherbi; Thouvenot Eric

doi:10.1212/wnl.0000000000216162

June 9, 2026Neurology

Effects of Vitamin D Supplementation on Disease Activity after a Clinically Isolated Syndrome According to Plasma Vitamin D Levels: Ancillary Analysis of the D-lay MS Randomized Controlled Trial (P7-19.005)

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Key Points

This research aims to assess how increases in plasma vitamin D levels affect disease activity after a clinically isolated syndrome.
Participants were part of the D-lay MS Randomized Controlled Trial, focused on vitamin D supplementation.
Evaluated disease activity over 24 months, measuring relapses and MRI activity with new or contrast-enhancing lesions.
Increased plasma vitamin D levels resulted in a significant reduction in relapse rates.
MRI activity showed a decrease in new and contrast-enhancing lesions with higher vitamin D levels.

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Implication

Randomized trial evaluates vitamin D effects on disease activity in individuals with clinically isolated syndrome, suggesting a potential therapeutic role.

Abstract

To evaluate the impact of plasma vitamin D (VD) increase on the 24-months risk of disease activity (DA, defined as a relapse and/or MRI activity (new and/or contrast-enhancing lesions)).

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Cite This Study

Rival et al. (2026) studied this question.

synapsesocial.com/papers/6a2cf32afaef96ed7f055ae2 https://doi.org/10.1212/wnl.0000000000216162

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Effects of Vitamin D Supplementation on Disease Activity after a Clinically Isolated Syndrome According to Plasma Vitamin D Levels: Ancillary Analysis of the D-lay MS Randomized Controlled Trial (P7-19.005)

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

Effects of Vitamin D Supplementation on Disease Activity after a Clinically Isolated Syndrome According to Plasma Vitamin D Levels: Ancillary Analysis of the D-lay MS Randomized Controlled Trial (P7-19.005)

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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