The mechanism study on moxibustion at Yintang Acupoint (EX-HN3) in treating allergic rhinitis based on Th1/Th2 balance

September 1, 2025Lishizhen medicine and materia medica research

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Key Points

This study aims to explore the effects and mechanisms of moxibustion at the Yintang acupoint on allergic rhinitis in a mouse model.
Female BALB/c mice were randomly divided into control, model, and moxibustion groups, with 10 mice each.
Allergic rhinitis was induced using ovalbumin injections combined with nasal administration.
Moxibustion was performed at the Yintang acupoint for 30 minutes daily for 7 days.
Mice in the model group showed increased scores for nasal symptoms, elevated serum IgE and IL-4 levels, and increased expression of IL-4, IL-5, and IL-10 mRNA in nasal tissues (P<0.05).
The moxibustion group exhibited decreased symptom scores and lower serum IgE and IL-4 levels, indicating a reversal of allergy symptoms (P<0.05).
Comparison of IFN-γ and IL-12 mRNA levels revealed a significant improvement in the moxibustion group compared to the model group (P<0.05).

Examines the effect of moxibustion treatment on allergic rhinitis symptoms in mice, suggesting a role in immune balance.

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REN et al. (2025) studied this question.

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