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June 9, 2026Neurology

Young-Adulthood Onset Chronic Cough as a Three Decades Prodrome of RFC1-related Autonomic and Sensory Neuropathy (P3-9.016)

Kyle Marden Goran Rakočević

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Key Points

This research aims to explore the connection between young-adulthood onset chronic cough and the long-term development of RFC1-related autonomic and sensory neuropathy.
Investigated the clinical manifestations of chronic cough in young adults over a 30-year period.
Assessed various genetic phenotypes involved in CANVAS disorder.
Identified a significant relationship between chronic cough and the onset of RFC1-related neuropathy.
Provided evidence supporting early intervention for symptomatic management and genetic counseling.

Implication

Investigates chronic cough as a precursor of RFC1-related neuropathy, indicating early detection possibilities.

Abstract

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Cite This Study

Marden et al. (2026) studied this question.

synapsesocial.com/papers/6a2cf32afaef96ed7f055b50 https://doi.org/10.1212/wnl.0000000000215120

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Keep reading

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Cerebellar ataxia, neuropathy and vestibular areflexia syndrome: a neurogenic cough prototype2024 · 11 citations
2Unnerving Cough in CANVAS: Cough Hypersensitivity Despite Airway Nerve Depletion2025 · 4 citations
3Chronic Cough and Cerebellar Ataxia With Neuropathy and Bilateral Vestibular Areflexia Syndrome (CANVAS): Screening for Mutations in Replication Factor C Subunit 1 (RFC1)2024 · 9 citations
4Cerebellar Ataxia, Neuropathy, and Vestibular Areflexia Syndrome (CANVAS): A case report of RFC1-associated diseaseCase Report · 2026
5RFC1-associated disease with an atypical parkinsonism syndrome phenotypeOriginal Research · 2026

RFC1 Repeat Expansion in Chronic Cough: Findings From the Korean Chronic Cough Registry2026
RFC1 AAGGG repeat expansion masquerading as Chronic Idiopathic Axonal Polyneuropathy2021
<i>RFC1</i> expansions are a common cause of idiopathic sensory neuropathy2021
Maternal and Fetal Safety Outcomes of Thrombolytics for Ischemic Stroke in PregnancyNeurology · 2026
Cenobamate in Focal-Onset Refractory and Super-Refractory Status EpilepticusNeurology · 2026

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