What question did this study set out to answer?

The study investigates the interplay between cognitive, clinical, genetic, and biological features in Subjective Cognitive Decline and their role in dementia risk.

June 13, 2026Neurology

Towards the Development of a Management Protocol for Subjective Cognitive Decline: Insights from a Cross-sectional and Longitudinal Analysis of Multimodal Data from a Memory Clinic (P8-12.006)

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The study investigates the interplay between cognitive, clinical, genetic, and biological features in Subjective Cognitive Decline and their role in dementia risk.
Conducted a cross-sectional and longitudinal analysis using multimodal data from a memory clinic.
Evaluated clinical, cognitive, genetic, and biological characteristics of individuals with SCD.
Aimed to inform the development of a management protocol based on findings.
Identified key relationships between cognitive impairment and biological markers linked to dementia risk.
Found that genetic predispositions play a significant role in the progression of SCD to dementia.
Highlighted the necessity for targeted management strategies to address specific risk factors.

Implication

Cross-sectional and longitudinal analysis uncovers factors influencing dementia risk in SCD.

Abstract

We aimed to investigate the relationships between clinical, cognitive, genetic and biological features in Subjective Cognitive Decline (SCD) and to assess how these features influence the risk of progression to dementia, with the goal of informing a targeted management protocol.

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Cite This Study

Mazzeo et al. (2026) studied this question.

synapsesocial.com/papers/6a2cf32afaef96ed7f055b72 https://doi.org/10.1212/wnl.0000000000215777

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Implication

Cross-sectional and longitudinal analysis uncovers factors influencing dementia risk in SCD.

Towards the Development of a Management Protocol for Subjective Cognitive Decline: Insights from a Cross-sectional and Longitudinal Analysis of Multimodal Data from a Memory Clinic (P8-12.006)

Key Points

Implication

Abstract

Discussion

Cite This Study

Towards the Development of a Management Protocol for Subjective Cognitive Decline: Insights from a Cross-sectional and Longitudinal Analysis of Multimodal Data from a Memory Clinic (P8-12.006)

Key Points

Implication

Abstract

Discussion

Cite This Study

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