Subclinical Seizures Contributing to Behavioral Symptoms in Bainbridge-Ropers Syndrome (ASXL3 Mutation): Improvement with Levetiracetam and Associated Metabolic Findings (P10-10.005)

X W Wang; Furqan Waseem; Salome Lembeck; Marwa Elamin; Shahram Izadyar

doi:10.1212/wnl.0000000000215078

June 9, 2026Neurology

Subclinical Seizures Contributing to Behavioral Symptoms in Bainbridge-Ropers Syndrome (ASXL3 Mutation): Improvement with Levetiracetam and Associated Metabolic Findings (P10-10.005)

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Key Points

This report aims to describe the relationship between subclinical seizures and behavioral symptoms in a patient with ASXL3 mutation.
Describes a single patient with ASXL3 mutation presenting behavioral dysregulation and new-onset seizures.
Details the administration of levetiracetam and monitoring of behavioral changes and metabolic findings.
Behavioral combativeness improved significantly after treatment with levetiracetam.
Metabolic abnormalities associated with the patient's condition were also discussed.

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Implication

Case report reveals improvement in behavioral symptoms from subclinical seizures with levetiracetam, highlighting metabolic issues.

Abstract

To describe a patient with ASXL3 mutation presenting with behavioral dysregulation and new-onset seizures, whose combativeness likely reflected subclinical seizures that improved with levetiracetam, and to discuss associated metabolic abnormalities.

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Cite This Study

Wang et al. (2026) studied this question.

synapsesocial.com/papers/6a2cf34dfaef96ed7f055c46 https://doi.org/10.1212/wnl.0000000000215078

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Subclinical Seizures Contributing to Behavioral Symptoms in Bainbridge-Ropers Syndrome (ASXL3 Mutation): Improvement with Levetiracetam and Associated Metabolic Findings (P10-10.005)

Key Points

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Implication

Abstract

Discussion

Cite This Study

Subclinical Seizures Contributing to Behavioral Symptoms in Bainbridge-Ropers Syndrome (ASXL3 Mutation): Improvement with Levetiracetam and Associated Metabolic Findings (P10-10.005)

Key Points

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Implication

Abstract

Discussion

Cite This Study

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