Uncovers leptomeningeal metastasis in CDH1-mutant invasive lobular carcinoma, indicating a new diagnostic approach.
The E-cadherin 1 (CDH-1) gene mutation is present in 30% to 60% of Invasive lobular carcinoma (ILC) of the breast. It results in loss of the E-cadherin–mediated adhesion, promoting subtle and atypical metastatic patterns.
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Pereira et al. (2026) studied this question.
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