Shows hESC-MPCs require ovarian function for muscle recovery in postmenopausal mice, indicating potential therapies for sarcopenia.
BACKGROUND: In postmenopausal women, ovarian function decreases rapidly and is accompanied by senescence-related changes in skeletal muscle. Administration of human embryonic stem cell-derived mesenchymal progenitor cells (hESC-MPCs) influenced the functional maintenance of perimenopausal ovaries in female mice. MATERIALS AND METHODS: ) or ovarian cells. RESULTS: or ovarian cells were co-introduced with hESC-MPCs. CONCLUSIONS: Maintenance of ovarian function was required for hESC-MPC-mediated recovery of damaged muscles in a postmenopausal mouse model via transcriptional remodeling associated with muscle regeneration.
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Jeong et al. (2026) studied this question.
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