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June 9, 2026Neurology

Unprecedented Progression of fALS With SOD1 and PFN1 Mutations: A Novel Case Report (P5-9.009)

Eleni Fafoutis Sisi Tang James Grogan

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Key Points

To describe a novel case of familial amyotrophic lateral sclerosis (fALS) and investigate the progression associated with SOD1 and PFN1 mutations.
Case report analysis that details the clinical progression of the condition.
Assessment of genetic mutations related to fALS.
The case presented an unprecedented rate of fALS progression associated with identified SOD1 and PFN1 mutations.

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Implication

Case report reveals novel findings about fALS progression driven by SOD1 and PFN1 mutations, suggesting new insights into treatment options.

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Cite This Study

Fafoutis et al. (2026) studied this question.

synapsesocial.com/papers/6a2cf34dfaef96ed7f055c9f https://doi.org/10.1212/wnl.0000000000217738

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