Gabapentin and Cognitive Impairment after Traumatic Brain Injury: A Multinational Cohort of 49,925 Patients (P2-3.015)

Key Points

This research examines the relationship between gabapentin use on the day of TBI and the risk of long-term cognitive impairment and mortality.
Analyzed data from a multinational cohort of 49,925 patients with TBI.
Assessed gabapentin use at the time of injury.
Examined associations with cognitive impairment and mortality outcomes.
Gabapentin use was associated with an increased risk of cognitive impairment.
Patients using gabapentin had higher mortality rates post-injury.
Findings indicate a potential link between gabapentin and negative cognitive outcomes.

Cohort study evaluates gabapentin's impact on cognitive impairment in TBI patients, suggesting potential risks.

To evaluate whether gabapentin use on the day of traumatic brain injury (TBI) is associated with risk of durable cognitive impairment and mortality.

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Thorman et al. (2026) studied this question.

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