Expanding the Phenotype of MOGAD: Multiple Cranial Neuropathies in a Patient with Seronegative-CSF-positive MOG IgG (P7-1.010)

Maria Andreina Hernandez; Eoin Flanagan; Kai Guo; Surabhi Beriwal; Natalie Brossard-Barbosa; Evan Huff; Zoe Williams; Lawrence Samkoff

doi:10.1212/wnl.0000000000216382

June 9, 2026Neurology

Expanding the Phenotype of MOGAD: Multiple Cranial Neuropathies in a Patient with Seronegative-CSF-positive MOG IgG (P7-1.010)

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Key Points

To explore the atypical clinical presentation of MOGAD in a patient with discordant serum and CSF MOG-IgG results.
Detailed clinical assessment of the patient's symptoms
Comparison of serum and CSF MOG-IgG levels
Identified multiple cranial neuropathies in the patient
MOG-IgG was negative in serum but positive in CSF, highlighting diagnostic complexity

Implication

Case report highlights unusual clinical phenotype of MOGAD in a seronegative CSF-positive individual, suggesting diagnostic challenges.

Abstract

To highlight an unusual clinical phenotype in a patient with Myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD), negative for MOG-IgG in serum but positive in CSF.

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Cite This Study

Hernandez et al. (2026) studied this question.

synapsesocial.com/papers/6a2cf34dfaef96ed7f055cff https://doi.org/10.1212/wnl.0000000000216382

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Expanding the Phenotype of MOGAD: Multiple Cranial Neuropathies in a Patient with Seronegative-CSF-positive MOG IgG (P7-1.010)

Key Points

Implication

Abstract

Discussion

Cite This Study

Expanding the Phenotype of MOGAD: Multiple Cranial Neuropathies in a Patient with Seronegative-CSF-positive MOG IgG (P7-1.010)

Key Points

Implication

Abstract

Discussion

Cite This Study

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