Brain Functional Connectivity Correlates of Pain Catastrophizing in Post-traumatic Headache (S23.002)

Catherine Chong; Simona Nikolova; Gina Dumkrieger; Michael Leonard; Dani Smith; Todd Schwedt; Federico Bighiani

doi:10.1212/wnl.0000000000213284

June 9, 2026Neurology

Brain Functional Connectivity Correlates of Pain Catastrophizing in Post-traumatic Headache (S23.002)

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Key Points

The study aims to explore the relationship between pain catastrophizing and brain functional connectivity in post-traumatic headache (PTH).
Participants completed the Pain Catastrophizing Scale (PCS) to assess their pain experience.
Magnetic resonance imaging (MRI) was utilized to measure resting-state functional connectivity patterns.
The study focused on individuals diagnosed with post-traumatic headache (PTH).
Significant correlations were found between higher PCS scores and altered functional connectivity in specific brain regions.
Individuals with greater pain catastrophizing exhibited distinct neural patterns compared to those with lower scores.
Brain connectivity may serve as a biomarker for understanding pain management strategies in PTH.

Implication

Investigates connections between pain perception and brain activity in headache sufferers, suggesting new treatment insights.

Abstract

To investigate whether individuals’ pain experience, as measured by the Pain Catastrophizing Scale (PCS), is associated with magnetic resonance imaging resting-state functional connectivity (rs-FC) patterns in individuals with PTH.

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Cite This Study

Chong et al. (2026) studied this question.

synapsesocial.com/papers/6a2cf34dfaef96ed7f055d0d https://doi.org/10.1212/wnl.0000000000213284

View Full Paper

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Brain Functional Connectivity Correlates of Pain Catastrophizing in Post-traumatic Headache (S23.002)

Key Points

Implication

Abstract

Discussion

Cite This Study

Brain Functional Connectivity Correlates of Pain Catastrophizing in Post-traumatic Headache (S23.002)

Key Points

Implication

Abstract

Discussion

Cite This Study

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