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June 9, 2026Neurology

PERM with GlyR and LRP4 Antibodies: A Rare Presentation Responsive to Plasma Exchange and Rituximab (P10-1.009)

Munther M. Queisi Amy Espinal Helene G. Rubeiz Josephe A. Honorat Daniel P. Kurz

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Key Points

To report a rare case of antibodies against GlyR and LRP4 presenting unique clinical features.
Utilized plasma exchange and rituximab for treatment.
Monitored symptoms and response to the interventions.
Significant improvement in symptoms following plasma exchange.
Rituximab contributed to the reduction of autoantibody levels.

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Implication

Case details rare autoimmune response to GlyR and LRP4 antibodies treated with plasma exchange and rituximab.

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Cite This Study

Queisi et al. (2026) studied this question.

synapsesocial.com/papers/6a2cf34dfaef96ed7f055d89 https://doi.org/10.1212/wnl.0000000000212885

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