Examines tau polymorphic contributions to disease progression in Alzheimer’s and CTE, indicating a need for targeted therapeutic strategies.
Tau aggregates into unique structural conformations, or polymorphs, in Alzheimer’s disease (AD) and AD-related dementias (ADRD) such as chronic traumatic encephalopathy (CTE), but the contribution of tau structure to disease progression remains unclear. We aimed to determine the polymorphic contribution to amplification and degradation of pathologic tau.
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Flavin et al. (2026) studied this question.
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