Conformational PLP-1 Antibodies as a Prognostic Biomarker in MOGAD (S6.010)

Q: What does this research mean for the field?

Conformational Proteolipid Protein 1 (PLP1)-IgG antibodies serve as a prognostic biomarker in Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disease (MOGAD). Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

Giacomo Greco; Stefano Masciocchi; Pietro Businaro; Federica Zuliani; Margherita Vacca; Chiara Morandi; Eleonora Rigoni; Giorgia Bruno; Sara Carta; Mario Risi; Manuela Lo Bianco; Antonio Covelli; Giulia Cellante; Silvia Sperandei; Alessandro Santagostino Barbone; Thomas Foiadelli; Alvino Bisecco; Erica Curti; Emanuela Claudia Turco; Antonio Gallo; Chiara Rocchi; Saif Huda; Margherita Mancardi; Massimiliano Di Filippo; Martina Fabris; Alberto Vogrig; Simone Vidale; Martino Ruggieri; Antonio Varone; Sara Mariotto; Georgina Arrambide; Álvaro Cobo Calvo; Romain Marignier; Elena Colombo; Matteo Gastaldi

doi:10.1212/wnl.0000000000216723

Key Points

This research investigates the use of Proteolipid Protein 1 (PLP1)-IgG as a prognostic biomarker in MOGAD.
Assessed PLP1-IgG in a large multicentric cohort
Evaluated prognostic significance
Identified PLP1-IgG as a viable prognostic biomarker for MOGAD
Findings suggest enhanced monitoring for clinical outcomes

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Implication

Assesses PLP-1 IgG as a prognostic biomarker in MOGAD, indicating its potential clinical use.

Abstract

We aimed to assess the potential of Proteolipid Protein 1 (PLP1)-IgG as a prognostic biomarker in a large multicentric MOGAD cohort.

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Cite This Study

Greco et al. (2026) studied this question.

synapsesocial.com/papers/6a2cf36efaef96ed7f055e05 https://doi.org/10.1212/wnl.0000000000216723

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Conformational PLP-1 Antibodies as a Prognostic Biomarker in MOGAD (S6.010)

Key Points

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Implication

Abstract

Discussion

Cite This Study

Conformational PLP-1 Antibodies as a Prognostic Biomarker in MOGAD (S6.010)

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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