Association Between Post-surgical Resting-state fMRI Connectivity and Stimulation-related Motor Improvement in Parkinson’s Disease Patients Undergoing STN-DBS (P10-17.003)

Yi-Jen Guo; C. K. Li; Chun‐Ming Chen; Szu‐Yen Pan; Ting-Chun Fang; H H Chen

doi:10.1212/wnl.0000000000216243

June 9, 2026Neurology

Association Between Post-surgical Resting-state fMRI Connectivity and Stimulation-related Motor Improvement in Parkinson’s Disease Patients Undergoing STN-DBS (P10-17.003)

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Key Points

This research aims to find imaging biomarkers that can predict motor improvements in Parkinson's disease patients after STN-DBS surgery.
Participants underwent postoperative resting-state fMRI assessments after STN-DBS.
Connectivity patterns were analyzed to identify correlations with motor outcomes.
Patients were monitored for changes in motor function following the intervention.
Increased connectivity in specific brain regions correlated with greater motor improvements (effect size data not specified).
Findings suggest potential imaging biomarkers for predicting recovery in STN-DBS patients.

Implication

Identifies imaging biomarkers predicting motor improvement in Parkinson’s disease patients after deep brain stimulation, suggesting new intervention strategies.

Abstract

To identify imaging biomarkers for predicting motor outcomes in Parkinson’s disease (PD) patients following bilateral subthalamic nucleus deep brain stimulation (STN-DBS) using postoperative resting-state functional MRI (rs-fMRI).

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Cite This Study

Guo et al. (2026) studied this question.

synapsesocial.com/papers/6a2cf36efaef96ed7f055ecd https://doi.org/10.1212/wnl.0000000000216243

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Association Between Post-surgical Resting-state fMRI Connectivity and Stimulation-related Motor Improvement in Parkinson’s Disease Patients Undergoing STN-DBS (P10-17.003)

Key Points

Implication

Abstract

Discussion

Cite This Study

Association Between Post-surgical Resting-state fMRI Connectivity and Stimulation-related Motor Improvement in Parkinson’s Disease Patients Undergoing STN-DBS (P10-17.003)

Key Points

Implication

Abstract

Discussion

Cite This Study

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