Severity of Tauopathy and Beta-amyloidosis in Logopenic Variant Primary Progressive Aphasia in Individuals With or Without a History of Developmental Dyslexia (N1.001)

Salvatore Spina; Zachary Miller; Sevinç Jakab; Margherita Tamagnini; Maria Luisa Mandelli; L. Kritikos; Hieu Pham; Siddarth Ramkrishnan; Mia Lin; Jaeyeon Kim; Mercedes Paredes; Howard Rosen; Lea Grinberg; William Seeley; Bruce Miller; Maria Luisa Gorno Tempini

doi:10.1212/wnl.0000000000216685

June 9, 2026Neurology

Severity of Tauopathy and Beta-amyloidosis in Logopenic Variant Primary Progressive Aphasia in Individuals With or Without a History of Developmental Dyslexia (N1.001)

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Key Points

To assess differences in the severity of Alzheimer’s disease-related changes in lvPPA patients based on their history of developmental dyslexia.
Patients with logopenic variant PPA were categorized based on their developmental dyslexia history.
Comparison was made regarding the severity of tauopathy and beta-amyloidosis.
Severity of tauopathy and beta-amyloidosis was significantly different between the two patient groups.
Patients with a history of developmental dyslexia exhibited altered neuropathological changes compared to non-LD patients.

Implication

Assesses Alzheimer’s neuropathological differences in lvPPA with and without developmental dyslexia, suggesting significant insights for diagnosis.

Abstract

To assess differences in the severity of Alzheimer’s disease neuropathological changes in disease epicenters of patients with logopenic variant PPA (lvPPA) with a history of learning differences/developmental dyslexia (LD) versus lvPPA patients without such history (non-LD).

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Cite This Study

Spina et al. (2026) studied this question.

synapsesocial.com/papers/6a2cf36efaef96ed7f055eff https://doi.org/10.1212/wnl.0000000000216685

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Severity of Tauopathy and Beta-amyloidosis in Logopenic Variant Primary Progressive Aphasia in Individuals With or Without a History of Developmental Dyslexia (N1.001)

Key Points

Implication

Abstract

Discussion

Cite This Study

Severity of Tauopathy and Beta-amyloidosis in Logopenic Variant Primary Progressive Aphasia in Individuals With or Without a History of Developmental Dyslexia (N1.001)

Key Points

Implication

Abstract

Discussion

Cite This Study

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