Limbic-predominant Age-related TDP-43 Encephalopathy (LATE): Clinical and Imaging Clues for an Underrecognized Dementia Entity (P8-12.004)

Valentina Velasco; Andres Ricaurte-Fajardo

doi:10.1212/wnl.0000000000217800

June 9, 2026Neurology

Limbic-predominant Age-related TDP-43 Encephalopathy (LATE): Clinical and Imaging Clues for an Underrecognized Dementia Entity (P8-12.004)

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Key Points

This research aims to clarify the clinical features and neuroimaging traits of limbic-predominant age-related TDP-43 encephalopathy (LATE) and its differences from Alzheimer’s disease.
Synthesis of current evidence regarding LATE's clinical presentation and imaging characteristics.
Emphasis on differentiating LATE from Alzheimer's disease and other neurodegenerative conditions.
Identified specific clinical symptoms and neuroimaging patterns unique to LATE.
Differentiated LATE from Alzheimer’s disease based on clinical and imaging clues.

Implication

Synthesis of clinical and imaging characteristics of LATE highlights its distinction from Alzheimer’s disease.

Abstract

To synthesize current evidence on the clinical presentation and neuroimaging characteristics of limbic-predominant age-related TDP-43 encephalopathy (LATE), emphasizing its differentiation from Alzheimer’s disease (AD) and other late-life neurodegenerative disorders.

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Cite This Study

Velasco et al. (2026) studied this question.

synapsesocial.com/papers/6a2cf393faef96ed7f055fb6 https://doi.org/10.1212/wnl.0000000000217800

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Limbic-predominant Age-related TDP-43 Encephalopathy (LATE): Clinical and Imaging Clues for an Underrecognized Dementia Entity (P8-12.004)

Key Points

Implication

Abstract

Discussion

Cite This Study

Limbic-predominant Age-related TDP-43 Encephalopathy (LATE): Clinical and Imaging Clues for an Underrecognized Dementia Entity (P8-12.004)

Key Points

Implication

Abstract

Discussion

Cite This Study

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