Utilizing the Circadian Clock to Enhance Temozolomide Efficacy in Pediatric Gliomas (N5.001)

Ella Nettnin; C B Wilson; CF Garcia; Fudhial Sayed; Maria Isabel Barros Guinle; Laura Prolo

doi:10.1212/wnl.0000000000212895

June 9, 2026Neurology

Utilizing the Circadian Clock to Enhance Temozolomide Efficacy in Pediatric Gliomas (N5.001)

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Key Points

This research aims to explore how the circadian clock influences chemotherapy treatment in pediatric high-grade gliomas.
Evaluated circadian regulation of therapy in pediatric high-grade gliomas.
Conducted in vitro and in vivo experiments to test the effects of circadian timing on temozolomide efficacy.
Circadian modulation significantly increased the effectiveness of temozolomide in both in vitro and in vivo settings.

Implication

Investigates circadian modulation to improve chemotherapy effectiveness in pediatric high-grade gliomas, suggesting potential therapeutic strategies.

Abstract

To investigate circadian regulation of therapy in pediatric high-grade gliomas (pHGG) and evaluate the potential of circadian modulation to enhance chemotherapy effectiveness both in vitro and in vivo.

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Cite This Study

Nettnin et al. (2026) studied this question.

synapsesocial.com/papers/6a2cf393faef96ed7f056096 https://doi.org/10.1212/wnl.0000000000212895

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Utilizing the Circadian Clock to Enhance Temozolomide Efficacy in Pediatric Gliomas (N5.001)

Key Points

Implication

Abstract

Discussion

Cite This Study

Utilizing the Circadian Clock to Enhance Temozolomide Efficacy in Pediatric Gliomas (N5.001)

Key Points

Implication

Abstract

Discussion

Cite This Study

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