Plasma Proteins in the SUR1–TRPM4 Pathway are Associated With Cerebral Edema and Contusion Expansion after Traumatic Brain Injury (P1-18.005)

Diana Monge Sanchez; Nasathapot Namphol; Aditya Kumar; Shreya Satheesh; Aurelia Cors; Anupama Rani; Margaux Miller; Erin McNally; Raemier Javelosa; Jane Hwang; Kaitlyn Hebig; Sirin Gandhi; Adam Eberle; Joshua Catapano; Semeon Afework; Thomas Donovan; Ethan Gaskin; Laura Snyder; Patrick Kochanek; H.E. Hinson; D Rajasundaram; Ruchira Jha

doi:10.1212/wnl.0000000000215701

Key Points

The study aims to identify plasma biomarkers in the SUR1-TRPM4 pathway related to cerebral edema and contusion expansion following traumatic brain injury.
Focused on assessing plasma protein levels associated with the SUR1-TRPM4 pathway.
Evaluated correlations between these biomarkers and the severity of cerebral edema and contusion expansion.
Detected significant associations between elevated plasma biomarkers and increased cerebral edema.
Identified the SUR1-TRPM4 pathway as potentially crucial in contusion expansion after TBI.

Implication

Identifies biomarkers linked to cerebral edema in traumatic brain injury, suggesting new avenues for treatment.

Abstract

To identify plasma biomarkers within the Sulfonylurea-receptor-1(SUR1)—transient-receptor-potential-cation-channel-M-member-4 (TRPM4) pathway associated with cerebral-edema and contusion-expansion after traumatic brain injury (TBI).

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Cite This Study

Sanchez et al. (2026) studied this question.

synapsesocial.com/papers/6a2cf393faef96ed7f0560ab https://doi.org/10.1212/wnl.0000000000215701

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Plasma Proteins in the SUR1–TRPM4 Pathway are Associated With Cerebral Edema and Contusion Expansion after Traumatic Brain Injury (P1-18.005)

Key Points

Implication

Abstract

Discussion

Cite This Study

Plasma Proteins in the SUR1–TRPM4 Pathway are Associated With Cerebral Edema and Contusion Expansion after Traumatic Brain Injury (P1-18.005)

Key Points

Implication

Abstract

Discussion

Cite This Study

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