Key result
Pharmacological inhibition of Sur1 by glibenclamide ameliorates edema, secondary hemorrhage, and tissue damage in models of central nervous system injury.
The Sur1-regulated NC(Ca-ATP) channel is a key mechanism of microvascular dysfunction and necrotic cell death in CNS injury, and its inhibition by glibenclamide shows promise in preclinical models and clinical trials.
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May support glibenclamide trials in CNS injury; leaves open confirmation of clinical benefit.
Simard et al. (2012) conducted a review in Central nervous system injury (cerebral ischemia, traumatic brain injury, spinal cord injury, subarachnoid hemorrhage). Glibenclamide was evaluated. Pharmacological inhibition of Sur1 by glibenclamide ameliorates edema, secondary hemorrhage, and tissue damage in models of central nervous system injury.
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