Novel Mechanistic Roles for TMEM106B in Regulating Lysosomal Inter-organelle Contact Sites and Misregulation in Frontotemporal Dementia (P6-13.005)

A Ly; Yvette C. Wong

doi:10.1212/wnl.0000000000215661

June 9, 2026Neurology

Novel Mechanistic Roles for TMEM106B in Regulating Lysosomal Inter-organelle Contact Sites and Misregulation in Frontotemporal Dementia (P6-13.005)

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Key Points

This research aims to explore the functions of TMEM106B in lysosomal dynamics and its relevance to Frontotemporal Dementia.
Examined TMEM106B’s role in lysosomes under both physiological and pathological conditions.
Analyzed inter-organelle contact sites involving lysosomes.
Identified the misregulation of TMEM106B as a contributing factor to Frontotemporal Dementia.
Showed novel functions of TMEM106B in regulating lysosomal contact with other organelles.

Implication

Uncovers TMEM106B's role in lysosomal contact sites and its implications for Frontotemporal Dementia.

Abstract

This study examines novel lysosomal functions of TMEM106B in physiological and pathological conditions and its contribution to Frontotemporal Dementia.

Discussion

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Cite This Study

Ly et al. (2026) studied this question.

synapsesocial.com/papers/6a2cf393faef96ed7f0560b6 https://doi.org/10.1212/wnl.0000000000215661

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Novel Mechanistic Roles for TMEM106B in Regulating Lysosomal Inter-organelle Contact Sites and Misregulation in Frontotemporal Dementia (P6-13.005)

Key Points

Implication

Abstract

Discussion

Cite This Study

Novel Mechanistic Roles for TMEM106B in Regulating Lysosomal Inter-organelle Contact Sites and Misregulation in Frontotemporal Dementia (P6-13.005)

Key Points

Implication

Abstract

Discussion

Cite This Study

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