What question did this study set out to answer?

This study aims to evaluate the toxicity and transplant outcomes of four carmustine-substituted conditioning regimens in lymphoma patients undergoing ASCT.

June 13, 2026Annals of HematologyOpen Access

Toxicity and efficacy of four carmustine-substituted conditioning regimens followed by autologous stem cell transplantation in lymphoma: a real-world comparative study

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Authors

YPYuyang PangShanghai Ninth People's Hospital XDXin DuGuangzhou University of Chinese Medicine WLWei LuDalian Medical University

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Implication

Real-world comparative study reveals distinct toxicity profiles of carmustine-substituted regimens in lymphoma after ASCT, suggesting personalized approaches.

Key Points

This study aims to evaluate the toxicity and transplant outcomes of four carmustine-substituted conditioning regimens in lymphoma patients undergoing ASCT.
Retrospective analysis of 80 lymphoma patients who underwent ASCT between January 2018 and December 2023.
Comparison of four conditioning regimens: BeEAM, CBV, CEAC, and SEAM.
Evaluation of primary endpoint (severe toxicity) and secondary outcomes (progression-free survival, overall survival, complete response rate, non-relapse mortality).
SEAM regimen showed significantly higher BNP elevation rates (61.1%, p = 0.040).
All BeEAM patients developed febrile neutropenia (p = 0.004), with increased platelet transfusions (median 6.5 units, p = 0.001).
CBV group had the highest cardiovascular adverse events (25.0%, p = 0.081), and CEAC showed the highest incidence of hypoproteinemia (100.0%, p = 0.006) and intestinal infection (81.3%, p = 0.069).

Cite This Study

Pang et al. (2026) studied this question.

synapsesocial.com/papers/6a2cf393faef96ed7f0560e0 https://doi.org/10.1007/s00277-026-07120-y

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Implication

Real-world comparative study reveals distinct toxicity profiles of carmustine-substituted regimens in lymphoma after ASCT, suggesting personalized approaches.

Toxicity and efficacy of four carmustine-substituted conditioning regimens followed by autologous stem cell transplantation in lymphoma: a real-world comparative study

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Implication

Key Points

Cite This Study

Toxicity and efficacy of four carmustine-substituted conditioning regimens followed by autologous stem cell transplantation in lymphoma: a real-world comparative study

Discussion

Member takes

Implication

Key Points

Cite This Study

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