Pyridoxine Supplementation Mitigates Levetiracetam Discontinuation and Behavioral Adverse Effects in Adults: A Retrospective Cohort Study (P6-11.004)

June 9, 2026Neurology

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Key Points

This study aims to assess if pyridoxine supplementation can decrease discontinuation rates and enhance behavioral tolerability associated with levetiracetam use in adults.
Retrospective cohort study analyzing adult patients on levetiracetam
Comparison made between groups receiving pyridoxine supplementation and those who did not
Pyridoxine supplementation is associated with a significant reduction in levetiracetam discontinuation rates.
Improved behavioral tolerability is noted in patients supplemented with pyridoxine compared to the control group.

Retrospective cohort study evaluates how pyridoxine affects levetiracetam tolerability in adults, suggesting potential therapeutic benefits.

To evaluate whether pyridoxine supplementation reduces levetiracetam discontinuation and improves behavioral tolerability in adult patients.

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Hamid et al. (2026) studied this question.

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