Age Gap as a Biomarker of Neurodegeneration and Functional Decline in Multiple Sclerosis: Insights into Racial Differences (P11-20.003)

Anas Nourelden; Fen Bao; Mawadda Abdelhai; Nidhi Patel; Abigail Biddix; Zaima Liaquat; Kalyan Yarraguntla; Jacob Rube; Carla Santiago‐Martinez; Anza Memon

doi:10.1212/wnl.0000000000215150

June 9, 2026Neurology

Age Gap as a Biomarker of Neurodegeneration and Functional Decline in Multiple Sclerosis: Insights into Racial Differences (P11-20.003)

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Key Points

This study aims to evaluate how age gap relates to neurodegeneration and functional decline in multiple sclerosis patients, particularly focusing on racial differences.
Evaluated the age gap in relation to neurodegeneration and functional outcomes in MS patients.
Analyzed data for both Black and White patients separately.
Utilized brain-predicted versus chronological ages to measure the age gap.
Found significant relationships between age gap and neurodegeneration in the overall MS cohort.
Identified distinct differences in microstructural and clinical outcomes between Black and White patients based on the age gap.
Suggests potential implications for personalized treatment strategies in MS management.

Implication

Evaluates age gap as a biomarker for neurodegeneration in MS, suggesting racial differences may influence outcomes.

Abstract

This study evaluates the relationship between age gap (brain-predicted minus chronological ages) and neurodegeneration, microstructural, clinical, and functional outcomes for the overall multiple sclerosis (MS) cohort and separately for Black and White patients.

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Cite This Study

Nourelden et al. (2026) studied this question.

synapsesocial.com/papers/6a2cf3b4faef96ed7f0561bf https://doi.org/10.1212/wnl.0000000000215150

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Age Gap as a Biomarker of Neurodegeneration and Functional Decline in Multiple Sclerosis: Insights into Racial Differences (P11-20.003)

Key Points

Implication

Abstract

Discussion

Cite This Study

Age Gap as a Biomarker of Neurodegeneration and Functional Decline in Multiple Sclerosis: Insights into Racial Differences (P11-20.003)

Key Points

Implication

Abstract

Discussion

Cite This Study

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