The Muscarinic Acetylcholine Receptor Antagonist Scopolamine Interrupts Medial Prefrontal Acetylcholine Dynamics During an Interval Timing Task in Freely Behaving Animals (P4-13.006)

June 9, 2026Neurology

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Key Points

This study aims to investigate the impact of scopolamine on acetylcholine dynamics in the medial prefrontal cortex during an interval timing task.
Animals were treated with scopolamine before performing an interval timing task.
Acetylcholine levels in the medial prefrontal cortex were measured during the task.
Analysis focused on how these levels change with scopolamine administration.
Scopolamine significantly decreased acetylcholine dynamics in the medial prefrontal cortex during the interval timing task.
Altered acetylcholine levels correlated with impaired performance on the timing task.

Reveals scopolamine disrupts acetylcholine dynamics in freely behaving animals, suggesting its effects on timing tasks.

To study how scopolamine affects acetylcholine dynamics within the medial prefrontal cortex (MFC) during an interval timing task.

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Zhang et al. (2026) studied this question.

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