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June 13, 2026Neurology

Long-term Efficacy of Adjunctive Cenobamate: Open-label Extension of a Randomized Clinical Study in a Multinational Asian Population (P11-10.005)

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Authors

LFLouis FerrariSK Life Science (United States)SLSang Kun LeeSeoul National University Hospital PYPeimin YuFudan University

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Implication

Randomized trial reports interim efficacy and safety of cenobamate in a multinational Asian population, suggesting positive outcomes.

Key Points

To evaluate the long-term efficacy and safety profile of adjunctive cenobamate.
Open-label extension of randomized clinical study YKP3089C035.
Multinational Asian population enrolled.
Interim efficacy and safety analyses reported.
Efficacy data suggest positive outcomes for cenobamate augmentation.
Safety profile aligns with previous findings from the randomized trial.

Cite This Study

Ferrari et al. (2026) studied this question.

synapsesocial.com/papers/6a2cf3b4faef96ed7f0562a9 https://doi.org/10.1212/wnl.0000000000215517

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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Long‐term efficacy of adjunctive cenobamate: Open‐label extension of a randomized, placebo‐controlled study in a multinational Asian population2026
2Efficacy and safety of adjunctive cenobamate based on patient etiology: Post-hoc analysis of YKP3089C017 randomized clinical trial2024 · 3 citations
3The cenobamate KORK study—A prospective monocenter observational study investigating cenobamate as an adjunctive therapy in refractory epilepsy, with comparisons to historical cohorts treated with add‐on lacosamide, perampanel, and brivaracetam2024 · 25 citations
4Early response rates with adjunctive cenobamate in uncontrolled focal seizures: Prospective analysis of a randomized, double‐blind, placebo‐controlled study in a multinational Asian population2025
5Beyond Clinical Trials: Cenobamate’s Effectiveness in Diverse Epilepsy Populations (P3-10.007)2026