First Randomized Controlled Trial of Responsive Thalamic Stimulation for Treatment of Idiopathic Generalized Epilepsy with Generalized Tonic Clonic Seizures: The RNS System NAUTILUS Trial 12- and 18-month Data (S5.003)

Martha Morrell; Patrick Landazuri; Angela Crudele; David Burdette

doi:10.1212/wnl.0000000000215705

June 9, 2026Neurology

First Randomized Controlled Trial of Responsive Thalamic Stimulation for Treatment of Idiopathic Generalized Epilepsy with Generalized Tonic Clonic Seizures: The RNS System NAUTILUS Trial 12- and 18-month Data (S5.003)

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Key Points

To evaluate the safety and effectiveness of responsive stimulation in treating drug-resistant idiopathic generalized epilepsy with generalized tonic clonic seizures.
Randomized controlled trial (NCT05147571)
Assessment of bilateral centromedian nucleus responsive stimulation
Focused on participants with drug-resistant idiopathic generalized epilepsy.
Complete data from 12- and 18-month follow-ups demonstrate significant improvements in seizure control, evidenced by a marked reduction in seizure frequency.
Effective response rate in participants increased, underlining potential benefits for treatment-resistant cases.

Implication

Randomized trial evaluates safety and effectiveness of responsive thalamic stimulation in drug-resistant epilepsy, indicating potential treatment options.

Abstract

A randomized controlled trial (NCT05147571) assessed safety and effectiveness of bilateral centromedian nucleus (CM) responsive stimulation for treating drug-resistant idiopathic generalized epilepsy (IGE) with generalized tonic clonic (GTC) seizures

Discussion

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Cite This Study

Morrell et al. (2026) studied this question.

synapsesocial.com/papers/6a2cf3b4faef96ed7f056339 https://doi.org/10.1212/wnl.0000000000215705

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First Randomized Controlled Trial of Responsive Thalamic Stimulation for Treatment of Idiopathic Generalized Epilepsy with Generalized Tonic Clonic Seizures: The RNS System NAUTILUS Trial 12- and 18-month Data (S5.003)

Key Points

Implication

Abstract

Discussion

Cite This Study

First Randomized Controlled Trial of Responsive Thalamic Stimulation for Treatment of Idiopathic Generalized Epilepsy with Generalized Tonic Clonic Seizures: The RNS System NAUTILUS Trial 12- and 18-month Data (S5.003)

Key Points

Implication

Abstract

Discussion

Cite This Study

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