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June 13, 2026International Journal of Medical MicrobiologyOpen Access

Mycobacterium tuberculosis identification and antibiotic resistance gene profiling using Nanopore sequencing: a new approach for tailoring more effective treatments for patients

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Authors

GLGen LiAWAo WuMGMingquan Guo

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Overview

Randomized trial evaluates TBseek's effectiveness in diagnosing tuberculosis and identifying drug resistance, emphasizing its potential in personalized treatments.

Key Points

  • The aim is to evaluate TBseek's performance for identifying Mycobacterium tuberculosis and antibiotic resistance in clinical samples.
  • Evaluated 185 clinical samples using TBseek, a multiplex targeted PCR nanopore sequencing test.
  • Compared diagnostic performance with Xpert PCR test, fluorescent microscopy, and culture.
  • Conducted sensitivity testing for antibiotic resistance in 76 TB positive culture samples.
  • TBseek achieved a sensitivity of 89.47% and specificity of 96.97%, with an AUC of 0.93.
  • 78.68% of TBseek-positive samples met the MTB-specific reads threshold within 1 hour.
  • TBseek had 100% sensitivity for resistance to rifampicin and high sensitivity for other antibiotics.

Cite This Study

Li et al. (2026) studied this question.

synapsesocial.com/papers/6a2cf3b4faef96ed7f05634dhttps://doi.org/10.1016/j.ijmm.2026.151725
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Also Consider

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  1. 1High-throughput nanopore targeted sequencing for efficient drug resistance assay of Mycobacterium tuberculosis2024 · 6 citations
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  4. 4Nanopore-based targeted next-generation sequencing of tissue samples for tuberculosis diagnosis2024 · 7 citations
  5. 5Rapid drug resistance prediction in positive <i>Mycobacterium tuberculosis</i> clinical samples using an extensive targeted next-generation sequencing panel2026 · 3 citations