What question did this study set out to answer?

This research aims to evaluate how effective and safe cenobamate is in treating primary generalized tonic-clonic seizures in individuals aged 12 years and older.

June 13, 2026Neurology

Efficacy and Safety of Adjunctive Cenobamate for the Treatment of Primary Generalized Tonic-clonic Seizures in Adults and Adolescents (P3-10.003)

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Authors

ESEvelyn ShihSK Life Science (United States)MBMichal BarUniversity of Ostrava MFMárk FarkasSemmelweis University

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Implication

Randomized trial assesses efficacy and safety of cenobamate for PGTC seizures in adolescents and adults, indicating potential for enhanced seizure control.

Key Points

This research aims to evaluate how effective and safe cenobamate is in treating primary generalized tonic-clonic seizures in individuals aged 12 years and older.
Randomized trial design
Included participants aged ≥12 years
Assessment of adjunctive treatment with cenobamate
Cenobamate effectively reduces the frequency of primary generalized tonic-clonic seizures.
Safety profile was acceptable with minimal adverse effects reported.
Statistical significance confirmed through specified metrics.

Cite This Study

Shih et al. (2026) studied this question.

synapsesocial.com/papers/6a2cf3b4faef96ed7f056356 https://doi.org/10.1212/wnl.0000000000215694

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Implication

Randomized trial assesses efficacy and safety of cenobamate for PGTC seizures in adolescents and adults, indicating potential for enhanced seizure control.

Efficacy and Safety of Adjunctive Cenobamate for the Treatment of Primary Generalized Tonic-clonic Seizures in Adults and Adolescents (P3-10.003)

Discussion

Member takes

Implication

Key Points

Cite This Study

Efficacy and Safety of Adjunctive Cenobamate for the Treatment of Primary Generalized Tonic-clonic Seizures in Adults and Adolescents (P3-10.003)

Discussion

Member takes

Implication

Key Points

Cite This Study

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