Randomized trial assesses alpha-synuclein assay sensitivity in diagnosing Parkinson’s disease and synucleinopathies, indicating diagnostic potential.
To determine the sensitivity and specificity of an alpha-synuclein seed amplification assay (αSyn-SAA) using skin punch biopsy for diagnosis of Parkinson’s disease (PD) and non-PD synucleinopathies (DLB and MSA) relative to normal controls.
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Gunzler et al. (2026) studied this question.
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